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Publication Title | SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES

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Text | SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES | 001



Substances and methods prohibited at all times (In- and Out-of-Competition)
Prohibited Substances
S1 ANABOLICAGENTS
• Dihydrotestosterone was renamed to its International Non-proprietary Name (INN) (androstanolone). 1-androsterone (3α-hydroxy-5α-androst-1-ene-17-one) was added in S1.a as an example of exogenous anabolic steroid.
• LGD-4033 and RAD140 were added as further examples of SARMs.
S2 PEPTIDEHORMONES,GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS
• For clarity and accuracy Section S2 was reorganized.
• ARA290 was removed as an example in this section
because current literature suggests it does not meet
inclusion criteria.
• Deslorelin, goserelin, nafarelin and triptorelin were
added as examples of 2.1.
• Growth Hormone fragments were included in 2.3 with
AOD-9604 and hGH 176-191 added as examples; CJC-1293 was added as example of GHRH and tabimorelin as a further example of GH secretagogue. GHRP-1, -3, -4, and -5 were added as examples
of GHRP.
• Thymosin- β4 and its derivatives, e. g. TB-500, were
added as example of prohibited growth factors.
• Cobalt: It is re-iterated that vitamin B12, which contains
cobalt, is not prohibited.
S3 BETA-2-AGONISTS
Dosing parameters of salbutamol were revised to make it clear that divided doses of salbutamol may not exceed 800 micrograms over any 12 hours (see figure).
Inhaled salbutamol – max. 1600 mcg over 24 hours But not to exceed 800 mcg over any 12 hours
12 24

0
200 mcg 200 mcg
200 mcg
200 mcg
200 mcg
200 mcg
200 mcg
200 mcg
Any 12 hour period: max. 800 mcg
• Tulobuterol was added as an example.
• The statement on the urinary thresholds was improved.
HORMONE AND METABOLIC S4 MODULATORS
• Clomifene is now stated by its INN.
• In the absence of an INN, the IUPAC name of GW1516, 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl) thiazol-5-yl)methylthio)phenoxy) acetic acid as well as an alternative name (GW501516) were included.
• SR9009, a Rev-Erb-α agonist, was added as an example of Activators of the AMP-activated protein kinase (AMPK).
1
SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES
2018 PROHIBITED LIST

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summary-major-modifications-and-explanatory-notes-001
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